Thursday, May 2, 2013

Career Profile: Patrick Kobina Arthur - May 2013




Patrick Kobina Arthur, PhD


Research and Teaching Faculty

Department of Biochemistry, Cell and Molecular Biology  

University of Ghana
Volta Road
P.O. Box LG 54
Legon-Accra


Email:   parthur@ug.edu.gh 

            parthur14@gmail.com


LinkedIN: http://ch.linkedin.com/pub/patrick-kobina-arthur/34/982/943

Dr. Patrick Kobina Arthur is lecturer at Department of Biochemistry, Cell and Molecular Biology of the University of Ghana. He obtained his PhD in Developmental Biochemistry at the University of Göttingen in Germany. He has undertaken several post-doctoral fellowships at the University of Maryland - College Park, USA, Swiss Federal Institute of Technology, Zurich (ETH-Zurich) and the Department of Chemistry, University of Cambridge in the UK. His research activities are in the area Chemical Systems Biology of Infectious Pathogens that comprises Infection Biology of Tuberculosis, etc, Chemical Biology of Fungal Metabolites, Advanced Imaging Techniques and Mass Spectrometry-based Proteomics of the perturbations caused in infectious pathogens by novel bioactive compounds. The mission of Dr. Arthur's research is towards the discovery and development of new antibiotics against tropical infectious diseases. Towards the discovery of novel anti-infective agents, his research group has presently isolated and screened more than three thousand distinct fungal species. The surprisingly high rate of the occurrence of anti-infective activities in the culture extracts of these fungi has led the group to develop a phenotypic array-based workflow as a key strategy. This allows for the comparison of the bioactive extracts of many standard antibiotics on the basis of their pattern of activities across different physiological conditions of the test organisms. Dr. Arthur’s group is currently in the process of isolating pure compounds from fungal extracts from the priority list. These compounds will be extensively characterized using NMR-structural elucidation, advanced imaging techniques and mass spectrometry-based proteomics to provide understanding of their mechanism of action to support pre-clinical development. Dr. Arthur has won a number of research grants from a number of organisations, such as DAAD-Germany, Grand Challenges Canada, TWAS-Italy, IFS-Sweden, and Gates Foundation/ NMIMR. Dr. Arthur was also selected as a fellow to attend the Lindau Nobel Laureates Meeting as well as a member of the Global Young Academy (GYA) in 2012 where he served as a non-voting member of the Executive Committee of the GYA from 2012-2013.
Check out his publications here: https://www.researchgate.net/profile/Patrick_Arthur
and his personal blog here: http://pakar1-corner.blogspot.com/…/career-profile-patrick-…


Professional appointments:

2009– date: Lecturer – Biochemistry, Cell and Molecular Biology, University of Ghana,
2011: Academic Guest/Visiting Scientist - Institute of Molecular Systems Biology, ETH-Zurich, Switzerland
2009: Visiting Scientist – Dept of Chemistry and Biochemistry, University of Maryland - College Park, MD
2008– 2009: Lecturer – Biochemistry, University of Cape Coast

Education:

2003 – 2008: PhD in Biochemistry, University of Göttingen – Germany
2001 – 2003: MSc in Molecular Biology, University of Göttingen – Germany
1997 – 2001: BSc in Biochemistry, University of Ghana, Legon

Teaching:
 

  • Cell Biology - Eukaryotic Cell Biology
  • Protein Biochemistry - Protein Structure and Mechanism of Action
  • Developmental Biology - Molecular Mechanisms
  • Intermediary Metabolism
  • Experimental Techniques in Biochemistry
  • Structure and Function of Biomolecules
  • Principles and Applications of Biotechnology
  • Bioprocess Engineering

Research Interests:

Chemical Biology and Proteomics in the Context of Infectious Diseases
  • Isolation and characterization of novel bioactive compounds from organisms originating from tropical-equatorial biodiversity hotspots, namely: 
             > Basidiomycetes (Wood Decaying Fungi),
             > Ascomycetes (Marine Endophytic Fungi)
             > Microalgae
             > Actinomycetes

  • Targeted Proteomics (Selected Reaction Monitoring) of Mycobacteria 
            (in collaboration with the Aebersold Lab, ETH-Zurich, Switzerland).
  • Chemical proteomics of target proteins in human parasites to specific novel bioactives and vice versa as well as corresponding off-target cellular proteins in humans.
  • Comparative and functional proteomics on target proteins & specific novel bioactives.
  • Clinical proteomics of novel bioactives, identification of biomarkers for in vivo activities.
  • Protein Biochemistry - Establish a library of 100 enzymes for molecular biology applications.
  • Molecular and structural dynamics of ribonucleoprotein complexes.


Re
search Grant Awards:

  1. Grand Challenges Canada - Stars in Global Health Round 4 (100,000 CAD) : May 2013 to Nov 2014(http://www.grandchallenges.ca/grantee-stars/0237-01/)
  2. Post-Doctoral fellowship Award by the Noguchi Memorial Institute for Medical Research ( )  2013-2015
  3. DAAD Equipment Grant  (23,000 euros) – 2012
  4. Short-term Postdoctoral Fellowship Grant  (15,000 euros)  – EMBO – ETH-Zurich – 2011
  5. Short-term Postdoctoral Fellowship Grant  (12,000 CHF) – SNSF– ETH-Zurich – 2011
  6.  German Government – ZAV/CIM/BMZ –Equipment Grant  (10,000 euros)  – 2010

Research publications:

1. Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway.
    Arthur PK, Alvarado LJ, Dayie TK., Protein Expr Purif. 2010 Nov 23. [Epub ahead of print]

2. Elr-type proteins protect Xenopus Dead end mRNA from miR-18-mediated clearance in the soma.
 
    Koebernick K, Loeber J, Arthur PK, Tarbashevich K, Pieler T. Proc Natl Acad Sci U S A.
    2010 Sep 14;107(37):16148-53. Epub 2010 Aug 30.

3. Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.
 
    Arthur PK, Claussen M, Koch S, Tarbashevich K, Jahn O, Pieler T. J Biol Chem.
    2009 Jul 24;284(30):19982-92. Epub 2009 May 20.





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